A comparative analysis of the efficacy of moxifloxacin and cefixime in the reduction of postoperative inflammatory sequelae after mandibular third molar surgery

Background/Aim. There is no scientific evidence that the prophylactic use of antibiotics as a part mandibular third molar surgery effective in suppressing postoperative pain, edema, trismus, and dry socket. The aim study was to investigate effects from fluoroquinolone (moxifloxacin) cephalosporin (cefixime) groups reducing inflammatory sequelae (pain, trismus), well possibly incidence socket after surgery. Methods. This double-blind completed by 157 subjects, comprising two (who received aforementioned antibiotics) control group, who placebo tablets. Subjects were assessed on first, second, seventh day following In course, patients monitored for occurrence, intensity, duration Results. Both antibiotics, especially moxifloxacin, had pronounced effect all trismus) most common complaints surgery, also contributed Conclusion. Antibiotic prophylaxis with cefixime and, reduced occurrence alleviated discomfort. It interesting, both socket, which not provoked inflammation. Therefore, further research into underlying mechanisms behind such an warranted.